News

Venturefest winners
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Scientists' breakthrough in production of biofuels
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Yorkshire Concept Board Meeting, December 2009
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Yorkshire Concept Board Meeting, September and October 2009
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Case Studies

Human Monoclonal Antibodies against the αIIβ3 Integrin

There are significant limitations in the use of mouse-derived antibodies, primarily because they elicit an immune response that blocks their effectiveness. This would be reduced if completely abolished if you use human antibodies. Furthermore the major therapeutic antibody ReoPro, which inhibits thrombosis, has been shown to react with both αIIbβ3 and αVβ3 with equal affinity and has been shown to distribute between platelets and endothelial cells. This coupled with a variety other interactions including the effect of shear stress means there is a potential to develop a range of antibodies of increased effectiveness. Thus specific anti-αIIbβ3 human monoclonal Fabs should have improved therapeutic characteristics and the strategy outlined below will allow the development of antibodies with different binding characteristics and therefore different and enhanced therapeutic potential.

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Toward the identification of novel therapeutics for individuals with a predisposition to breast cancer

People who have a genetic pre-disposition to breast cancer have an 80% chance of developing the disease, and face tough choices regarding treatment options. This University of Sheffield team have established a novel approach for the development of new treatment options, which exploits our understanding of how breast cancer cells differ from their normal counterparts. Funding from YC is enabling us to establish rigorous proof of commercial concept as well as to develop first generation technology for the identification of novel, targeted therapeutic leads. Proposal sponsored by University of Sheffield and approved at the June 2009 Yorkshire Fund Board meeting.

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Welcome to Yorkshire Concept:

Proof of Commercial Concept Fund 2007-2010

Yorkshire Concept is a new project Fund designed to stimulate the commercialisation of research and knowledge-based activities in the Higher Education Institutions (HEIs) across the Yorkshire and the Humber region. It is funded jointly, on the principle of matched funding, by the Regional Development Agency, Yorkshire Forward, and the Higher Education Institutions themselves.

Activities will focus on supporting projects which enhance potential for a new product or process to become commercially viable and on forging collaborations between higher education and private sectors to encourage innovation.

Our Partners

Central to the success of the Yorkshire Concept : Proof of Commercial Fund are the partnerships between the Fund, the Higher Education Institutions (HEIs) in the region and Yorkshire Forward, the Regional Development Agency.

Allocated funding is matched 50% from the Fund sourced by Yorkshire Forward and 50% from the HEIs with £3 million being contributed from each source over a 3 year period, creating a £6m Fund. In addition we work closely with the Yorkshire Enterprise Fellowship scheme

Our partners are listed below:

Venturefest 2010

We are excited to be attending Venturefest 2010. The Fund will showcase around 30 of its propositions in the university showcase staff area, demonstrating the commercial potential of a wide range of science, technology and knowledge propositions from the region's higher education and research sector. There will also be a private area where business managers, academic inventors, investors and industrial partners can meet, talk and network. Find out more about Venturefest 2010.

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